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Sterilization Q&A

  • Asked March 22nd, 2009

    Ability to control dose range in a gamma irradiator is directly related to the design of the irradiator. There are irradiator designs that specifically target a tight dose range delivery where a dose range as tight as +/- 10% of the target dose can be obtained. If a large scale irradiator is being used, dose ranges of +/-10 kGy can also be obtained by controlling the density of the product and how the product carton is presented to the irradiator, i.e., reduce the target width of the product carton when it is presented to the irradiation source. Personnel at the irradiation facility are experts in determining the best method of presenting the product to the irradiation source in order to achieve optimum control of the dose range. In addition to dose range, the dose rate too can be controlled in order to protect biological based products during the irradiation process.

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